Buzz Bissinger interviews Tony La Russa concerning the state of baseball in 2005. They discuss La Russa's time managing the Oakland Athletics and St. Louis Cardinals. The conversation frequently returns to the influence of money and performance enhancing drugs. They also discuss their book Three Nights in August, the book Moneyball, La Russa's management style, and how much longer La Russa will manage a baseball team.

During the question-and-answer session with Joe Epstein, Tony talks about animals and his non-profit organization ARF.