Margaret Chesney, of UCSF, moderates a discussion with Lawrence K. Altman and Neal Nathanson. Nathanson speaks about the state of the art in AIDS medicines. Altman speaks about the introduction of human experimentation in the fight against AIDS and wonders "who goes first?". He spends a good amount of time pondering the implication of self-experimentation by the researchers, advocating no third party should consent to an experiment if a researcher has not undertaken the experiment themselves.